Hair Loss
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 Sophora Angustifolia  Adenogen Sophora

The Adenogen in addition to adenosine, contains extracts of Sophora Angustifolia's root. The Sophora also helps to inhibit the enzyme 5-alpha-reductase, thus, the effectiveness (not clearly shown) of Adenogen can be attributed not only to adenosine but also to additional substances that make up the lotion.


 Our Opinion  We believe it is possible that the product works, that the theory is valid, but the results presented are between poor and moderate.

Maybe it's worth trying in patients who have failed with Minoxidil and/or Finasteride, but we must also take into consideration the additional costs of the product. In the long run can be a very expensive treatment.

The Adenogen was approved as a cosmetic product for the hair. This means that neither the Japanese authorities themselves claim that works for androgenic alopecia.

The official product costs about U$S65.-, but some laboratories produce more economic alternative versions and even with some combinations with Minoxidil.

Adenosine: another treatment for alopecia / baldness

Adenogen Adenosina On December 1, 2004, the Japanese company Shiseido claimed to have found a new solution to combatandrogenic alopecia.

The news caused a stir and generated high expectations for those who fought (and fight) against hair loss. However, the scientific community remained outside of any studies about it, except for those presented by the Shiseido Research Center.

The long awaited product went on sale on March 21, 2005, under the name of Adenogen.

The Company Shiseido is well-respected for having fragrances and cosmetics of high quality. Its unique design makes more than one to run to buy a product because of a nice container and not because of its contents.



Adenogen


The Adenogen is composed of:
  • Adenosine [Active Ingredient]
  • Beta-glycyrrhetinic Acid
  • Menthol
  • Dipropileno Glycol
  • Root Extract of Sophora Angustifolia
  • Ethyl Ester - D-Panthenol The Adenosine is a purine nucleotide formed by the union of adenine and a ribose ring.

    Adenine is one of four nitrogenous bases that make up DNA. Serves as energy transport in the form of adenosine triphosphate and adenosine diphosphate and -Through a transduction system- also acts as a second intracellular messenger (Cyclic adenosine monophosphate).

    Shiseido studies indicate that the loss of hair and hair follicle weakening due to a decrease in levels of Fibroblast Growth Factor 7 (FGF7).

    The intracellular messenger (Cyclic Adenosine Monophosphate/CAM) generated by adenosine, elevated levels of growth of FGF7 extending the phase of hair growth and developing by promoting longevity.

    Adenosine is found in every cell in our body, which does not mean that the drug belongs to a "natural Treatments" group...

    Many people experience mixing different drugs (especially Minoxidil) seeking better results for treating their own alopecia. This is not only automedication but its like playing on a home-made laboratory.

    Of course we do not recommend doing this kind of experiments with any drug, but it is important to emphasize that with Adenosine an overdose can be fatal.

    Do not forget that has long time in the market been used to treat arrhythmias and reverse supraventricular tachycardia. If the Minoxidil is not a "toy", much less will be Adenosine.

    Beyond the mode of action, we can observe the effectiveness of Adenosine in a more objective way: photographs.
    Here we can see the results after six months of treatment with Adenogen:



    This photograph is the the one that Shiseido presented in the official document, saying that it is a patient with a significant improvement.
    Unfortunately we could not assess the effectiveness of the product on our own. We didn't have access to more photographs.

    We believe that it is possible that the product works, that the theory is valid, but the results are between poor and moderate.

    Maybe will be worth trying -without much expectation of success- in those patients who have failed with Minoxidil and/or Finasteride.

    The Adenogen was approved as a cosmetic product for the hair. This means that the Japanese authorities themselves cannot claim that works for androgenic alopecia.

    The official product costs about U$S65.-, but some laboratories have produced alternative versions and even some combinations with Minoxidil.

    Remember, you should never start a treatment without first consulting a professional.

 
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